Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial.
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SUBMITTER: Kremsner PG
PROVIDER: S-EPMC8610426 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
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Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial.
Kremsner Peter G PG Ahuad Guerrero Rodolfo Andrés RA Arana-Arri Eunate E Aroca Martinez Gustavo Jose GJ Bonten Marc M Chandler Reynaldo R Corral Gonzalo G De Block Eddie Jan Louis EJL Ecker Lucie L Gabor Julian Justin JJ Garcia Lopez Carlos Alberto CA Gonzales Lucy L Granados González María Angélica MA Gorini Nestor N Grobusch Martin P MP Hrabar Adrian D AD Junker Helga H Kimura Alan A Lanata Claudio F CF Lehmann Clara C Leroux-Roels Isabel I Mann Philipp P Martinez-Reséndez Michel Fernando MF Ochoa Theresa J TJ Poy Carlos Alberto CA Reyes Fentanes Maria Jose MJ Rivera Mejia Luis Maria LM Ruiz Herrera Vida Veronica VV Sáez-Llorens Xavier X Schönborn-Kellenberger Oliver O Schunk Mirjam M Sierra Garcia Alexandra A Vergara Itziar I Verstraeten Thomas T Vico Marisa M Oostvogels Lidia L
The Lancet. Infectious diseases 20211123 3
<h4>Background</h4>Additional safe and efficacious vaccines are needed to control the COVID-19 pandemic. We aimed to analyse the efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate.<h4>Methods</h4>HERALD is a randomised, observer-blinded, placebo-controlled, phase 2b/3 clinical trial conducted in 47 centres in ten countries in Europe and Latin America. By use of an interactive web response system and stratification by country and age group (18-60 years and ≥61 years), adults with ...[more]
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