Elevated REG3α predicts refractory aGVHD in patients who received steroids-ruxolitinib as first-line therapy.

ABSTRACT: We started a single-arm, phase II, open-label, prospective clinical trial using steroids-ruxolitinib as the first-line therapy for intermediate- to high-risk aGVHD (NCT04397367). Here, we report the association of a biomarker panel (sST2, REG3α, sTNFR1, IL-6 and IL-8) with responses to GVHD therapy. The novel first-line therapy for 39 patients with newly diagnosed aGVHD consisted of 1 mg/kg methylprednisolone and 5 mg/day ruxolitinib. The serum concentrations of the biomarkers were prospectively detected at planned time points. Of the 39 patients, the complete response rate at day 28 was 82.05%. In patients who achieved CR, the concentrations of REG3α (P₁₄ = 0.01; P₂₈ = 0.10) and sTNFR1 (P₁₄ = 0.42; P₂₈ = 0.04) declined at day 14 and day 28 compa

SUBMITTER: Yang J 

PROVIDER: S-EPMC8610441 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature