Genetic Polymorphisms Affecting Tacrolimus Metabolism and the Relationship to Post-Transplant Outcomes in Kidney Transplant Recipients.

ABSTRACT:

Background

Tacrolimus is a key drug in kidney transplantation with a narrow therapeutic index. However, whether tacrolimus exposure variability affects clinical outcomes and adverse reactions remains unknown.

Objective

Our study investigated the factors that influence tacrolimus exposure in kidney transplantation recipients and the relationship between tacrolimus concentration and clinical outcomes and adverse reactions.

Settings and methods

We examined the effect of tacrolimus concentration on clinical outcomes and adverse reactions in 201 kidney transplantation recipients, and identified clinical and pharmacogenetic factors that explain tacrolimus exposure.

Results

The CYP3A5 genotype was clearly associated with dose-adjusted trough blood tacrolimus concentra

SUBMITTER: Cheng F 

PROVIDER: S-EPMC8610755 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature