Avatrombopag: A Review in Thrombocytopenia.

ABSTRACT: Avatrombopag (Doptelet^®) is an orally administered second generation thrombopoietin receptor agonist (TPO-RA) approved for the treatment of primary chronic immune thrombocytopenia (ITP) in adult patients who are refractory or have an unsatisfactory response to other treatments, as well as for the treatment of thrombocytopenia in adult patients with chronic liver disease (CLD) scheduled to undergo an invasive procedure. In phase III studies, avatrombopag was associated with a significantly greater platelet response than placebo in patients with chronic ITP, and was superior to placebo in reducing the requirement for platelet transfusion or rescue procedures for bleeding caused by surgery in patients with CLD with a platelet count < 50 × 10⁹/L at baseline. Longer term d

SUBMITTER: Markham A 

PROVIDER: S-EPMC8610948 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature