Assessment of histological characteristics, imaging markers, and rt-PA susceptibility of ex vivo venous thrombi.

ABSTRACT: Venous thromboembolism is a significant source of morbidity and mortality worldwide. Catheter-directed thrombolytics is the primary treatment used to relieve critical obstructions, though its efficacy varies based on the thrombus composition. Non-responsive portions of the specimen often remain in situ, which prohibits mechanistic investigation of lytic resistance or the development of diagnostic indicators for treatment outcomes. In this study, thrombus samples extracted from venous thromboembolism patients were analyzed ex vivo to determine their histological properties, susceptibility to lytic therapy, and imaging characteristics. A wide range of thrombus morphologies were observed, with a dependence on age and etymology of the specimen. Fibrinolytic inhibitors including PAI-1, alpha 2-

SUBMITTER: Hendley SA 

PROVIDER: S-EPMC8610976 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature