Human Liver Stem Cell Transplantation Alleviates Liver Fibrosis in a Rat Model of CCl₄-Induced Liver Fibrosis.

ABSTRACT:

Background and objectives

Mesenchymal stem cells (MSCs) elicit therapeutic effects against liver fibrosis in animal models. Human liver stem cells (HLSCs) are cells isolated from human liver tissue that have mesenchymal morphology and express MSC markers. HLSCs also possess intrahepatic stem cell properties. We introduce a rat model of liver fibrosis and trans-portal transplantation of HLSC to demonstrate alleviation of liver fibrosis.

Methods and results

Liver fibrosis was induced by intraperitoneal injection of Carbon tetrachloride (CCl₄). Sprague Dawley rats underwent simultaneous partial hepatectomy of the left hepatic lobe and HLSC transplantation via the portal vein. Gross appearance of the liver observed following CCl₄ injection showed cholestasi

SUBMITTER: Lee JH 

PROVIDER: S-EPMC8611308 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature