Identification of miRNA Regulatory Networks and Candidate Markers for Fracture Healing in Mice.

ABSTRACT:

Background

It is important to improve the understanding of the fracture healing process at the molecular levels, then to discover potential miRNA regulatory mechanisms and candidate markers.

Methods

Expression profiles of mRNA and miRNA were obtained from the Gene Expression Omnibus database. We performed differential analysis, enrichment analysis, protein-protein interaction (PPI) network analysis. The miRNA-mRNA network analysis was also performed.

Results

We identified 499 differentially expressed mRNAs (DEmRs) that were upregulated and 534 downregulated DEmRs during fracture healing. They were mainly enriched in collagen fibril organization and immune response. Using the PPI network, we screened 10 hub genes that were upregulated and 10 hub genes downregulated wit

SUBMITTER: Li X 

PROVIDER: S-EPMC8611357 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature