Acid suppressant use in association with incidence and severe outcomes of COVID-19: a systematic review and meta-analysis.

ABSTRACT:

Purpose

Several observational studies have presented conflicting results on the association between the use of proton pump inhibitors (PPIs) or histamine H2 receptor antagonist (H2RA) and the risk of coronavirus disease 2019 (COVID-19). This systematic review and meta-analysis aimed to examine this association.

Methods

In July 2021, PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science were searched for articles investigating the relationship between the two main acid suppressants and COVID-19. Studies showing the effect estimates as hazard ratio (HR) for severe outcomes or incidence of COVID-19 were evaluated using a random-effects model.

Results

A total of 15 retrospective cohort studies with 18,109 COVID-19 cases were included in the cu

SUBMITTER: Kim HB 

PROVIDER: S-EPMC8611395 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature