Investigation of the impact of SARS-CoV infection on the immunologic status and lung function after 15 years.

ABSTRACT:

Background

We investigate the long-term effects of SARS-CoV on patients' lung and immune systems 15 years post-infection. SARS-CoV-2 pandemic is ongoing however, another genetically related beta-coronavirus SARS-CoV caused an epidemic in 2003-2004.

Methods

We enrolled 58 healthcare workers from Peking University People's Hospital who were infected with SARS-CoV in 2003. We evaluated lung damage by mMRC score, pulmonary function tests, and chest CT. Immune function was assessed by their serum levels of globin, complete components, and peripheral T cell subsets. ELISA was used to detect SARS-CoV-specific IgG antibodies in sera.

Results

After 15 years of disease onset, 19 (36.5%), 8 (34.6%), and 19 (36.5%) subjects had impaired DL (CO), RV, and FEF_25-75, respe

SUBMITTER: Li J 

PROVIDER: S-EPMC8611627 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature