Genetic diversity and immunogenicity of the merozoite surface protein 1 C-terminal 19-kDa fragment of Plasmodium ovale imported from Africa into China.

ABSTRACT:

Background

Merozoite surface protein 1 (MSP1) plays an essential role in erythrocyte invasion by malaria parasites. The C-terminal 19-kDa region of MSP1 has long been considered one of the major candidate antigens for a malaria blood-stage vaccine against Plasmodium falciparum. However, there is limited information on the C-terminal 19-kDa region of Plasmodium ovale MSP1 (PoMSP1₁₉). This study aims to analyze the genetic diversity and immunogenicity of PoMSP1₁₉.

Methods

A total of 37 clinical Plasmodium ovale isolates including Plasmodium ovale curtisi and Plasmodium ovale wallikeri imported from Africa into China and collected during the period 2012-2016 were used. Genomic DNA was used to amplify P. ovale curtisi (poc) msp1₁₉ (pocmsp1₁₉

SUBMITTER: Xu Q 

PROVIDER: S-EPMC8611641 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature