The role of vascular dementia associated genes in patients with Alzheimer's disease: A large case-control study in the Chinese population.

ABSTRACT:

Aim

The role of vascular dementia (VaD)-associated genes in Alzheimer's disease (AD) remains elusive despite similar clinical and pathological features. We aimed to explore the relationship between these genes and AD in the Chinese population.

Methods

Eight VaD-associated genes were screened by a targeted sequencing panel in a sample of 3604 individuals comprising 1192 AD patients and 2412 cognitively normal controls. Variants were categorized into common variants and rare variants according to minor allele frequency (MAF). Common variant (MAF ≥ 0.01)-based association analysis was conducted by PLINK 1.9. Rare variant (MAF < 0.01) association study and gene-based aggregation testing of rare variants were performed by PLINK 1.9 and Sequence Kernel Association Test-Optimal (SK

SUBMITTER: Xiao X 

PROVIDER: S-EPMC8611771 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature