Genetic alteration and clonal evolution of primary glioblastoma into secondary gliosarcoma.

ABSTRACT:

Aims

Secondary gliosarcoma (SGS) rarely arises post treatment of primary glioblastoma multiforme (GBM), and contains gliomatous and sarcomatous components. The origin and clonal evolution of SGS sarcomatous components remain uncharacterized. Therapeutic radiation is mutagenic and can induce sarcomas in patients with other tumor phenotypes, but possible causal relationships between radiotherapy and induction of SGS sarcomatous components remain unexplored. Herein, we investigated the clonal origin of SGS in a patient with primary GBM progressing into SGS post-radiochemotherapy.

Methods

Somatic mutation profile in GBM and SGS was examined using whole-genome sequencing and deep-whole-exome sequencing. Mutation signatures were characterized to investigate relationships between r

SUBMITTER: Li J 

PROVIDER: S-EPMC8611784 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature