Disruption of rack1 suppresses SHH-type medulloblastoma formation in mice.

ABSTRACT:

Introduction

Medulloblastoma (MB) is a malignant pediatric brain tumor that arises in the cerebellar granular neurons. Sonic Hedgehog subtype of MB (SHH-MB) is one of the major subtypes of MB in the clinic. However, the molecular mechanisms underlying MB tumorigenesis are still not fully understood.

Aims

Our previous work demonstrated that the receptor for activated C kinase 1 (Rack1) is essential for SHH signaling activation in granule neuron progenitors (GNPs) during cerebellar development. To investigate the potential role of Rack1 in MB development, human MB tissue array and SHH-MB genetic mouse model were used to study the expression of function of Rack1 in MB pathogenesis.

Results

We found that the expression of Rack1 was significantly upregulated in the majorit

SUBMITTER: Liu F 

PROVIDER: S-EPMC8611787 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature