Theoretical potential for endometrial cancer prevention through primary risk factor modification: Estimates from the EPIC cohort.

ABSTRACT: Endometrial cancer (EC) incidence rates vary ~10-fold worldwide, in part due to variation in EC risk factor profiles. Using an EC risk model previously developed in the European EPIC cohort, we evaluated the prevention potential of modified EC risk factor patterns and whether differences in EC incidence between a European population and low-risk countries can be explained by differences in these patterns. Predicted EC incidence rates were estimated over 10 years of follow-up for the cohort before and after modifying risk factor profiles. Risk factors considered were: body mass index (BMI, kg/m² ), use of postmenopausal hormone therapy (HT) and oral contraceptives (OC) (potentially modifiable); and, parity, ages at first birth, menarche and menopause (environmentally conditioned,

SUBMITTER: Fortner RT 

PROVIDER: S-EPMC8611794 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature