Immunogenicity trends 1 and 3 months after second BNT162B2 vaccination among healthcare workers in Israel.

ABSTRACT:

Objectives

We evaluated the antibody response to the BNT162B2 vaccine among healthcare workers (HCWs) to identify factors associated with decreased immunogenicity.

Methods

This prospective cohort study included consenting HCWs who completed a questionnaire regarding background illnesses, medications, and post-vaccination allergic reactions or rash. All HCWs were tested for anti-spike antibodies (LIAISON SARS-CoV-2 S1/S2 IgG assay) 1 and 3 months after the second vaccine dose. A multivariate mixed linear model was adjusted to participants' data and fit to predict antibody levels after the second BNT162B2 vaccine dose, based on antibody levels at 1 month and the slope between 3 months and 1 month. Multivariate analyses identified factors associated with lower antibody levels.<

SUBMITTER: Shachor-Meyouhas Y 

PROVIDER: S-EPMC8611821 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature