Parsed synthesis of pyocyanin via co-culture enables context-dependent intercellular redox communication.

ABSTRACT:

Background

Microbial co-cultures and consortia are of interest in cell-based molecular production and even as "smart" therapeutics in that one can take advantage of division of labor and specialization to expand both the range of available functions and mechanisms for control. The development of tools that enable coordination and modulation of consortia will be crucial for future application of multi-population cultures. In particular, these systems would benefit from an expanded toolset that enables orthogonal inter-strain communication.

Results

We created a co-culture for the synthesis of a redox-active phenazine signaling molecule, pyocyanin (PYO), by dividing its synthesis into the generation of its intermediate, phenazine carboxylic acid (PCA) from the first strain, fol

SUBMITTER: Chun K 

PROVIDER: S-EPMC8611841 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature