The role of spatial embedding in mouse brain networks constructed from diffusion tractography and tracer injections.

ABSTRACT: Diffusion MRI tractography is the only noninvasive method to measure the structural connectome in humans. However, recent validation studies have revealed limitations of modern tractography approaches, which lead to significant mistracking caused in part by local uncertainties in fiber orientations that accumulate to produce larger errors for longer streamlines. Characterizing the role of this length bias in tractography is complicated by the true underlying contribution of spatial embedding to brain topology. In this work, we compare graphs constructed with ex vivo tractography data in mice and neural tracer data from the Allen Mouse Brain Connectivity Atlas to random geometric surrogate graphs which preserve the low-order distance effects from each modality in order to quantify the role

SUBMITTER: Trinkle S 

PROVIDER: S-EPMC8611903 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature