Causal effects of atrial fibrillation on brain white and gray matter volume: a Mendelian randomization study.

ABSTRACT:

Background

Atrial fibrillation (AF) and brain volume loss are prevalent in older individuals. We aimed to assess the causal effect of atrial fibrillation on brain volume phenotypes by Mendelian randomization (MR) analysis.

Methods

The genetic instrument for AF was constructed from a previous genome-wide association study (GWAS) meta-analysis (15,993 AF patients and 113,719 controls of European ancestry). The outcome summary statistics for head-size-normalized white or gray matter volume measured by magnetic resonance imaging were provided by a previous GWAS of 33,224 white British participants in the UK Biobank. Two-sample MR by the inverse variance-weighted method was performed, supported by pleiotropy-robust MR sensitivity analysis. The causal estimates for the effect of A

SUBMITTER: Park S 

PROVIDER: S-EPMC8611907 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature