Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China.

ABSTRACT:

Background

Hand, foot and mouth disease (HFMD) is caused by a variety of enterovirus serotypes and the etiological spectrum worldwide has changed since a large scale of outbreaks occurred in 1997.

Methods

A large number of clinical specimens of HFMD patients were collected in Xiangyang and genotyping was performed by qRT-PCR, conventional PCR amplification and sequencing. Among the 146 CV-A5 detected cases, the complete genome sequences of representative strains were determined for genotyping and for recombination analysis.

Results

It was found that CV-A5 was one of the six major serotypes that caused the epidemic from October 2016 to December 2017. Phylogenetic analyses based on the VP1 sequences showed that these CV-A5 belonged to the genotype D which dominantly cir

SUBMITTER: Yu Y 

PROVIDER: S-EPMC8611921 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature