Survival-associated N⁶-adenosine methyltransferase signatures in lung squamous cell carcinoma and clinical verification.

ABSTRACT:

Background

N⁶-methyladenine (m⁶A) is the most common modification of mRNA and IncRNA in higher organisms. m⁶A has been confirmed to be related to the formation and progression of tumors and m⁶A-related genes can be used as prognostic biomarkers in a variety of tumors. However, there have been no similar studies on lung squamous cell carcinoma. The main purpose of this study was aimed to explore the differential expression of m⁶A-related genes in lung squamous cell carcinoma tissues and its relationship with patient clinical prognosis.

Methods

We integrated three m⁶A writers that catalyze the methylation of adenine on mRNA molecules. The training set including 501 patients with LUSC was collected from The Cance

SUBMITTER: Qu J 

PROVIDER: S-EPMC8611943 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature