Mutational signatures among young-onset testicular cancers.

ABSTRACT:

Background

Incidence of testicular cancer is highest among young adults and has been increasing dramatically for men born since 1945. This study aimed to elucidate the factors driving this trend by investigating differences in mutational signatures by age of onset.

Methods

We retrieved somatic variant and clinical data pertaining to 135 testicular tumors from The Cancer Genome Atlas. We compared mutational load, prevalence of specific mutated genes, mutation types, and mutational signatures between age of onset groups (< 30 years, 30-39 years, ≥ 40 years) after adjusting for subtype. A recursively partitioned mixture model was utilized to characterize combinations of signatures among the young-onset cases.

Results

Mutational load was significantly higher among older-o

SUBMITTER: Mealey NE 

PROVIDER: S-EPMC8611954 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature