Effects of buprenorphine/lorcaserin mixtures on preference for heroin, cocaine, or saline over food using a concurrent choice procedure in rhesus monkeys.

ABSTRACT:

Background

The opioid epidemic continues despite the availability of medications, including buprenorphine, for opioid use disorder (OUD); identifying novel and effective treatments is critical for decreasing the prevalence of OUD and ending this crisis. Buprenorphine alone does not markedly attenuate abuse-related effects of nonopioids. Treatment outcomes might be improved by combining buprenorphine with a second medication targeting substance use disorder (SUD), such as lorcaserin, a serotonin_2C (5-HT_2C) receptor selective agonist that decreases abuse-related effects of drugs from several pharmacological classes in preclinical studies.

Methods

This study investigated the effectiveness of buprenorphine/lorcaserin mixtures to decrease preference for hero

SUBMITTER: Gerak LR 

PROVIDER: S-EPMC8612090 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature