Conserved genetic signatures parcellate cardinal spinal neuron classes into local and projection subsets.

ABSTRACT: Motor and sensory functions of the spinal cord are mediated by populations of cardinal neurons arising from separate progenitor lineages. However, each cardinal class is composed of multiple neuronal types with distinct molecular, anatomical, and physiological features, and there is not a unifying logic that systematically accounts for this diversity. We reasoned that the expansion of new neuronal types occurred in a stepwise manner analogous to animal speciation, and we explored this by defining transcriptomic relationships using a top-down approach. We uncovered orderly genetic tiers that sequentially divide groups of neurons by their motor-sensory, local-long range, and excitatory-inhibitory features. The genetic signatures defining neuronal projections were tied to neuronal birth date

SUBMITTER: Osseward PJ 

PROVIDER: S-EPMC8612134 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature