Identification of a MarR Subfamily That Regulates Arsenic Resistance Genes.

ABSTRACT: In this study, comprehensive analyses were performed to determine the function of an atypical MarR homolog in Achromobacter sp. strain As-55. Genomic analyses of Achromobacter sp. As-55 showed that this marR is located adjacent to an arsV gene. ArsV is a flavin-dependent monooxygenase that confers resistance to the antibiotic methylarsenite [MAs(III)], the organoarsenic compound roxarsone(III) [Rox(III)], and the inorganic antimonite [Sb(III)]. Similar marR genes are widely distributed in arsenic-resistant bacteria. Phylogenetic analyses showed that these MarRs are found in operons predicted to be involved in resistance to inorganic and organic arsenic species, so the subfamily was named MarR_ars. MarR_ars orthologs have three conserve

SUBMITTER: Yu Y 

PROVIDER: S-EPMC8612249 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature