Transcriptional Regulation of Congocidine (Netropsin) Biosynthesis and Resistance.

ABSTRACT: The production of specialized metabolites by Streptomyces bacteria is usually temporally regulated. This regulation is complex and frequently involves both global and pathway-specific mechanisms. Streptomyces ambofaciens ATCC23877 produces several specialized metabolites, including spiramycins, stambomycins, kinamycins and congocidine. The production of the first three molecules has been shown to be controlled by one or several cluster-situated transcriptional regulators. However, nothing is known regarding the regulation of congocidine biosynthesis. Congocidine (netropsin) belongs to the family of pyrrolamide metabolites, which also includes distamycin and anthelvencins. Most pyrrolamides bind into the minor groove of DNA, specifically in A/T-rich regions, which gives them numerous

SUBMITTER: Vingadassalon A 

PROVIDER: S-EPMC8612282 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature