Interobserver Agreement on Automated Metabolic Tumor Volume Measurements of Deauville Score 4 and 5 Lesions at Interim ¹⁸F-FDG PET in Diffuse Large B-Cell Lymphoma.

ABSTRACT: Metabolic tumor volume (MTV) on interim PET (I-PET) is a potential prognostic biomarker for diffuse large B-cell lymphoma (DLBCL). Implementation of MTV on I-PET requires a consensus on which semiautomated segmentation method delineates lesions most successfully with least user interaction. Methods used for baseline PET are not necessarily optimal for I-PET because of lower lesional SUVs at I-PET. Therefore, we aimed to evaluate which method provides the best delineation quality for Deauville score (DS) 4-5 DLBCL lesions on I-PET at the best interobserver agreement on delineation quality and, second, to assess the effect of lesional SUV_max on delineation quality and performance agreement. Methods: DS 4-5 lesions from 45 I-PET scans were delineated using 6 semiautomated me

SUBMITTER: Zwezerijnen GJC 

PROVIDER: S-EPMC8612315 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature