PSMA- and GRPR-Targeted PET: Results from 50 Patients with Biochemically Recurrent Prostate Cancer.

ABSTRACT: Novel radiopharmaceuticals for PET are being evaluated for the diagnosis of biochemical recurrence (BCR) of prostate cancer (PC). We compared the gastrin-releasing peptide receptor-targeting ⁶⁸Ga-RM2 with the prostate-specific membrane antigen (PSMA)-targeting ⁶⁸Ga-PSMA11 and ¹⁸F-DCFPyL. Methods: Fifty patients underwent both ⁶⁸Ga-RM2 PET/MRI and ⁶⁸Ga-PSMA11 (n = 23) or ¹⁸F-DCFPyL (n = 27) PET/CT at an interval ranging from 1 to 60 d (mean ± SD, 15.8 ± 17.7 d). SUV_max was collected for all lesions. Results: ⁶⁸Ga-RM2 PET was positive in 35 and negative in 15 of the 50 patients. ⁶⁸Ga-PSMA11/¹⁸F-DCFPyL PET was positive in 37 and negative in 13 of the 50 pat

SUBMITTER: Baratto L 

PROVIDER: S-EPMC8612333 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature