Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans.

ABSTRACT:

Aim

Experimental studies provided numerous evidence that caloric/dietary restriction may improve health and increase the lifespan of laboratory animals, and that the interplay among molecules that sense cellular stress signals and those regulating cell survival can play a crucial role in cell response to nutritional stressors. However, it is unclear whether the interplay among corresponding genes also plays a role in human health and lifespan.

Methods

Literature about roles of cellular stressors have been reviewed, such as amino acid deprivation, and the integrated stress response (ISR) pathway in health and aging. Single nucleotide polymorphisms (SNPs) in two candidate genes (GCN2/EIF2AK4 and CHOP/DDIT3) that are closely involved in the cellular stress respons

SUBMITTER: Yashin AI 

PROVIDER: S-EPMC8612394 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature