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Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines.

ABSTRACT: Asymmetric hydrogenation of unsaturated morpholines has been developed by using a bisphosphine-rhodium catalyst bearing a large bite angle. With this approach, a variety of 2-substituted chiral morpholines could be obtained in quantitative yields and with excellent enantioselectivities (up to 99% ee). The hydrogenated products could be transformed into key intermediates for bioactive compounds.

SUBMITTER: Li M

PROVIDER: S-EPMC8612400 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines.

Li Mingxu M Zhang Jian J Zou Yashi Y Zhou Fengfan F Zhang Zhenfeng Z Zhang Wanbin W

Chemical science 20211028 45

Asymmetric hydrogenation of unsaturated morpholines has been developed by using a bisphosphine-rhodium catalyst bearing a large bite angle. With this approach, a variety of 2-substituted chiral morpholines could be obtained in quantitative yields and with excellent enantioselectivities (up to 99% ee). The hydrogenated products could be transformed into key intermediates for bioactive compounds. ...[more]

PMID: 34909146

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