Cannabinoid-2 Agonism with AM2301 Mitigates Morphine-Induced Respiratory Depression.

ABSTRACT: Introduction: An escalating number of fatalities resulting from accidental opioid overdoses typically attributed to respiratory depression continue to define the opioid epidemic. Opioid respiratory depression results from a decrease in reflexive inspiration within the preBötzinger complex in the brainstem. Objective: Cannabinoid receptor agonism is reported to enhance opioid analgesia, yet whether cannabinoids enhance or inhibit opioid-induced respiratory depression is unknown. Methods: Studies herein sought to define the roles of cannabinoid-1 receptor (CB1R) and cannabinoid-2 receptor (CB2R) on respiratory depression using selective agonists alone and in combination with morphine in male mice. Results: Using whole body plethysmography, the nonselective CB1R an

SUBMITTER: Wiese BM 

PROVIDER: S-EPMC8612410 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature