Hippocampus-Prefrontal Coupling Regulates Recognition Memory for Novelty Discrimination.

ABSTRACT: Recognition memory provides the ability to distinguish familiar from novel objects and places, and is important for recording and updating events to guide appropriate behavior. The hippocampus (HPC) and medial prefrontal cortex (mPFC) have both been implicated in recognition memory, but the nature of HPC-mPFC interactions, and its impact on local circuits in mediating this process is not known. Here we show that novelty discrimination is accompanied with higher theta activity (4-10 Hz) and increased c-Fos expression in both these regions. Moreover, theta oscillations were highly coupled between the HPC and mPFC during recognition memory retrieval for novelty discrimination, with the HPC leading the mPFC, but not during initial learning. Principal neurons and interneurons in the mPFC respon

SUBMITTER: Wang C 

PROVIDER: S-EPMC8612471 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature