Association between voriconazole exposure and Sequential Organ Failure Assessment (SOFA) score in critically ill patients.

ABSTRACT: Therapeutic drug monitoring (TDM) is essential for voriconazole to ensure optimal drug exposure, mainly in critically ill patients for whom voriconazole demonstrated a large variability. The study aimed at describing factors associated with trough voriconazole concentrations in critically ill patients and evaluating the impact of voriconazole concentrations on adverse effects. A 2-year retrospective multicenter cohort study (NCT04502771) was conducted in six intensive care units. Adult patients who had at least one voriconazole TDM were included. Univariable and multivariable linear regression analyses were performed to identify predictors of voriconazole concentrations, and univariable logistic regression analysis, to study the relationship between voriconazole concentrations and adverse

SUBMITTER: Bienvenu AL 

PROVIDER: S-EPMC8612507 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature