Whole Blood Expression Pattern of Inflammation and Redox Genes in Mild Alzheimer's Disease.

ABSTRACT:

Background

Although Alzheimer's disease (AD) is associated with alterations of the central nervous system, this disease has an echo in blood that might represent a valuable source of biomarkers for improved diagnosis, prognosis and for monitoring drug response.

Methods

We performed a targeted transcriptomics study on 38 mild Alzheimer's disease (AD) patients and 38 matched controls for evaluating the expression levels of 136 inflammation and 84 redox genes in whole blood. Patients were diagnosed as mild AD based on altered levels of total TAU, phospho-TAU and Abeta_(1-42) in cerebrospinal fluid, and Abeta_(1-40), Abeta_(1-42) and total TAU levels in plasma. Whenever possible, blood and brain comparisons were made using public datasets.

Result

SUBMITTER: Milanesi E 

PROVIDER: S-EPMC8612672 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature