Correct regionalization of a tissue primordium is essential for coordinated morphogenesis.

ABSTRACT: During organ development, tubular organs often form from flat epithelial primordia. In the placodes of the forming tubes of the salivary glands in the Drosophila embryo, we previously identified spatially defined cell behaviors of cell wedging, tilting, and cell intercalation that are key to the initial stages of tube formation. Here, we address what the requirements are that ensure the continuous formation of a narrow symmetrical tube from an initially asymmetrical primordium whilst overall tissue geometry is constantly changing. We are using live-imaging and quantitative methods to compare wild-type placodes and mutants that either show disrupted cell behaviors or an initial symmetrical placode organization, with both resulting in severe impairment of the invagination. We find tha

SUBMITTER: Sanchez-Corrales YE 

PROVIDER: S-EPMC8612734 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature