Response competition between neurons and antineurons in the mushroom body.

ABSTRACT: The mushroom bodies of Drosophila contain circuitry compatible with race models of perceptual choice. When flies discriminate odor intensity differences, opponent pools of αβ core Kenyon cells (on and off αβ_c KCs) accumulate evidence for increases or decreases in odor concentration. These sensory neurons and "antineurons" connect to a layer of mushroom body output neurons (MBONs) which bias behavioral intent in opposite ways. All-to-all connectivity between the competing integrators and their MBON partners allows for correct and erroneous decisions; dopaminergic reinforcement sets choice probabilities via reciprocal changes to the efficacies of on and off KC synapses; and pooled inhibition between αβ_c KCs can establish equivalence with the drift-diffusion formalism kn

SUBMITTER: Vrontou E 

PROVIDER: S-EPMC8612741 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature