Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast.

ABSTRACT: To understand the genetic basis and selective forces acting on longevity, it is useful to examine lifespan variation among closely related species, or ecologically diverse isolates of the same species, within a controlled environment. In particular, this approach may lead to understanding mechanisms underlying natural variation in lifespan. Here, we analyzed 76 ecologically diverse wild yeast isolates and discovered a wide diversity of replicative lifespan (RLS). Phylogenetic analyses pointed to genes and environmental factors that strongly interact to modulate the observed aging patterns. We then identified genetic networks causally associated with natural variation in RLS across wild yeast isolates, as well as genes, metabolites, and pathways, many of which have never been associated wit

SUBMITTER: Kaya A 

PROVIDER: S-EPMC8612763 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature