Oxidative Stress Disrupted Prepubertal Rat Testicular Development after Xenotransplantation.

ABSTRACT: In the past two decades, testicular tissue grafting and xenografting have been well established, with the production of fertilization-competent sperm in some studies. However, few studies have been carried out to observe the development of grafted prepubertal testicular tissue of rats and compare the biological differences between in situ testis and grafted testis. In this study, we established the prepubertal testicular tissue xenografting model using a 22-day-old rat and evaluated certain parameters, including testicular histology, testosterone production, and ultrastructure of the grafted testes. We also assessed gene expression of cell proliferation markers, testicular cell markers, and antioxidative defense system. Our results showed that 47 days after transplantation, intratesticular

SUBMITTER: Ma YB 

PROVIDER: S-EPMC8612805 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature