3D Printing of Microgel Scaffolds with Tunable Void Fraction to Promote Cell Infiltration.

ABSTRACT: Granular, microgel-based materials have garnered interest as promising tissue engineering scaffolds due to their inherent porosity, which can promote cell infiltration. Adapting these materials for 3D bioprinting, while maintaining sufficient void space to enable cell migration, can be challenging, since the rheological properties that determine printability are strongly influenced by microgel packing and void fraction. In this work, a strategy is proposed to decouple printability and void fraction by blending UV-crosslinkable gelatin methacryloyl (GelMA) microgels with sacrificial gelatin microgels to form composite inks. It is observed that inks with an apparent viscosity greater than ≈100 Pa s (corresponding to microgel concentrations ≥5 wt%) have rheological properties that enable extr

SUBMITTER: Seymour AJ 

PROVIDER: S-EPMC8612872 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature