Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study.
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SUBMITTER: McCarthy JS
PROVIDER: S-EPMC8612936 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
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Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study.
McCarthy James S JS Yalkinoglu Özkan Ö Odedra Anand A Webster Rebecca R Oeuvray Claude C Tappert Aliona A Bezuidenhout Deon D Giddins Marla J MJ Dhingra Satish K SK Fidock David A DA Marquart Louise L Webb Lachlan L Yin Xiaoyan X Khandelwal Akash A Bagchus Wilhelmina M WM
The Lancet. Infectious diseases 20211026 12
<h4>Background</h4>M5717 is the first plasmodium translation elongation factor 2 inhibitor to reach clinical development as an antimalarial. We aimed to characterise the safety, pharmacokinetics, and antimalarial activity of M5717 in healthy volunteers.<h4>Methods</h4>This first-in-human study was a two-part, single-centre clinical trial done in Brisbane, QLD, Australia. Part one was a double-blind, randomised, placebo-controlled, single ascending dose study in which participants were enrolled i ...[more]
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