Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: an international microbiology and drug evaluation prospective substudy (BARNARDS).
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ABSTRACT:
SUBMITTER: Thomson KM
PROVIDER: S-EPMC8612937 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
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Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: an international microbiology and drug evaluation prospective substudy (BARNARDS).
Thomson Kathryn M KM Dyer Calie C Liu Feiyan F Sands Kirsty K Portal Edward E Carvalho Maria J MJ Barrell Matthew M Boostrom Ian I Dunachie Susanna S Farzana Refath R Ferreira Ana A Frayne Francis F Hassan Brekhna B Jones Ellis E Jones Lim L Mathias Jordan J Milton Rebecca R Rees Jessica J Chan Grace J GJ Bekele Delayehu D Mahlet Abayneh A Basu Sulagna S Nandy Ranjan K RK Saha Bijan B Iregbu Kenneth K Modibbo Fatima F Uwaezuoke Stella S Zahra Rabaab R Shirazi Haider H Syed Najeeb U NU Mazarati Jean-Baptiste JB Rucogoza Aniceth A Gaju Lucie L Mehtar Shaheen S Bulabula Andre N H ANH Whitelaw Andrew A van Hasselt Johan G C JGC Walsh Timothy R TR
The Lancet. Infectious diseases 20210809 12
<h4>Background</h4>Sepsis is a major contributor to neonatal mortality, particularly in low-income and middle-income countries (LMICs). WHO advocates ampicillin-gentamicin as first-line therapy for the management of neonatal sepsis. In the BARNARDS observational cohort study of neonatal sepsis and antimicrobial resistance in LMICs, common sepsis pathogens were characterised via whole genome sequencing (WGS) and antimicrobial resistance profiles. In this substudy of BARNARDS, we aimed to assess t ...[more]
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