CIDEA expression in SAT from adolescent girls with obesity and unfavorable patterns of abdominal fat distribution.

ABSTRACT:

Objective

This study investigated whether variations in cell death-inducing DNA fragmentation factor alpha subunit-like effector A (CIDEA) mRNA expression and protein levels are modulated by the pattern of abdominal fat distribution in adolescent girls with obesity.

Methods

This study recruited 35 adolescent girls with obesity and characterized their abdominal fat distribution by magnetic resonance imaging. Participants had only a periumbilical/abdominal (n = 14) or a paired abdominal and gluteal subcutaneous adipose tissue (SAT) biopsy (n = 21). CIDEA expression was determined by reverse transcription-polymerase chain reaction, CIDEA protein level by Western blot, and the turnover of adipose lipids and adipocytes by ² H₂ O labeling. In six girls, a sec

SUBMITTER: Tarabra E 

PROVIDER: S-EPMC8612981 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature