Copper-Binding Peptides Attenuate Microglia Inflammation through Suppression of NF-kB Pathway.

ABSTRACT:

Scope

Activation of microglia, the resident immune cells of the central nervous system, has been related to the etiology and progression of neurodegenerative diseases; thus, finding novel approaches to suppress the neuroinflammatory process is of utmost relevance.

Methods and results

The anti-inflammatory activity of whey Cu-, Fe-, and Zn-binding peptides and their possible underlying mechanism of action were evaluated in microglia. Whey metal-binding peptides decreased nitric oxide production and tumor necrosis factor α (TNF-α) at mRNA and protein levels by stimulated BV-2 microglia in comparison to the control with no peptide treatment. The hydrophobicity, specific sequences, and possible synergistic effects seem to play a role. Cu-binding peptides (Cu-bp) presented anti-i

SUBMITTER: Caetano-Silva ME 

PROVIDER: S-EPMC8612997 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature