Filgotinib in Rheumatoid Arthritis: A Profile of Its Use.

ABSTRACT: Filgotinib (Jyseleca^®), an oral Janus kinase (JAK) inhibitor, is approved as monotherapy or in combination with methotrexate to treat moderate to severe active rheumatoid arthritis (RA) in adults who have an inadequate response or intolerance to one or more disease-modifying antirheumatic drugs (DMARDs). In phase 3 trials, once-daily filgotinib was generally well tolerated and associated with an improvement in RA signs and symptoms as well as physical function in patients with an inadequate response to ongoing methotrexate, an inadequate response to ongoing conventional synthetic DMARDs plus an inadequate response or intolerance to prior biologic DMARDs, or limited or no prior exposure to methotrexate. In addition, filgotinib was noninferior to adalimumab in terms of low disease

SUBMITTER: Kim ES 

PROVIDER: S-EPMC8613087 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature