Biocompatibility and feasibility of VisiPlate, a novel ultrathin, multichannel glaucoma drainage device.

ABSTRACT:

Background

Glaucoma is the leading cause of blindness worldwide. Glaucoma drainage devices and minimally invasive glaucoma surgeries (MIGS) often present with tradeoffs in safety and durability of efficacy. Using a rabbit model, we examined the biocompatibility and feasibility of VisiPlate, a novel, ultrathin, tubeless subconjunctival shunt comprised of a network of microchannels.

Methods

Six naive female New Zealand White rabbits received implants (three only in the right eye with contralateral eye untreated and three in both eyes) composed of a 400-nm-thick aluminum oxide core coated with 2 µm of parylene-C, manufactured with microelectromechanical systems (MEMS) techniques. Tonometry, slit lamp exam, clinical exam, fluorescein patency testing, and histopathology were perf

SUBMITTER: Kao BW 

PROVIDER: S-EPMC8613174 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature