Phosphatidylcholine restores neuronal plasticity of neural stem cells under inflammatory stress.

ABSTRACT: The balances between NSCs growth and differentiation, and between glial and neuronal differentiation play a key role in brain regeneration after any pathological conditions. It is well known that the nervous tissue shows a poor recovery after injury due to the factors present in the wounded microenvironment, particularly inflammatory factors, that prevent neuronal differentiation. Thus, it is essential to generate a favourable condition for NSCs and conduct them to differentiate towards functional neurons. Here, we show that neuroinflammation has no effect on NSCs proliferation but induces an aberrant neuronal differentiation that gives rise to dystrophic, non-functional neurons. This is perhaps the initial step of brain failure associated to many neurological disorders. Interestingly, we

SUBMITTER: Magaquian D 

PROVIDER: S-EPMC8613233 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature