An integrated host-microbiome response to atrazine exposure mediates toxicity in Drosophila.

ABSTRACT: The gut microbiome produces vitamins, nutrients, and neurotransmitters, and helps to modulate the host immune system-and also plays a major role in the metabolism of many exogenous compounds, including drugs and chemical toxicants. However, the extent to which specific microbial species or communities modulate hazard upon exposure to chemicals remains largely opaque. Focusing on the effects of collateral dietary exposure to the widely used herbicide atrazine, we applied integrated omics and phenotypic screening to assess the role of the gut microbiome in modulating host resilience in Drosophila melanogaster. Transcriptional and metabolic responses to these compounds are sex-specific and depend strongly on the presence of the commensal microbiome. Sequencing the genomes of all abundant micr

SUBMITTER: Brown JB 

PROVIDER: S-EPMC8613235 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature