Altered estradiol-dependent cellular Ca²⁺ homeostasis and endoplasmic reticulum stress response in Premenstrual Dysphoric Disorder.

ABSTRACT: Premenstrual Dysphoric Disorder (PMDD) is characterized by debilitating mood symptoms in the luteal phase of the menstrual cycle. Prior studies of affected women have implicated a differential response to ovarian steroids. However, the molecular basis of these patients' differential response to hormone remains poorly understood. We performed transcriptomic analyses of lymphoblastoid cell lines (LCLs) derived from women with PMDD and asymptomatic controls cultured under untreated (steroid-free), estradiol-treated (E2), and progesterone-treated (P4) conditions. Weighted gene correlation network analysis (WGCNA) of transcriptomes identified four gene modules with significant diagnosis x hormone interactions, including one enriched for neuronal functions. Next, in a gene-level analysis compari

SUBMITTER: Li HJ 

PROVIDER: S-EPMC8613306 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature