Integrating network pharmacological and experimental models to investigate the therapeutic effects of baicalein in glaucoma.

ABSTRACT:

Background

Traditional Chinese medicine (TCM) has a long history of treating glaucoma with remarkable effects, but there is no clear conclusion on its mechanism.

Methods

Network pharmacology and molecular docking were used to analyze the mechanism and targets of TCM in the treatment of glaucoma, and baicalein was used to treat chronic ocular hypertension animal models rats for observation.

Results

The results of animal experiments showed that baicalein could significantly reduce intraocular pressure (IOP) in a rat model of chronic ocular hypertension and protect the structure of the retina and optic nerve, as shown by hematoxylin-eosin (H&E) staining and transmission electron microscopy (TEM). Reducing the apoptosis of retinal ganglion cells (RGCs) by upregulating the

SUBMITTER: Yang J 

PROVIDER: S-EPMC8613988 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature