Profile of gene expression changes during estrodiol-17β-induced feminization in the Takifugu rubripes brain.

ABSTRACT:

Background

As the critical tissue of the central nervous system, the brain has been found to be involved in gonad development. Previous studies have suggested that gonadal fate may be affected by the brain. Identifying brain-specific molecular changes that occur during estrodiol-17β (E₂) -induced feminization is crucial to our understanding of the molecular control of sex differentiation by the brains of fish.

Results

In this study, the differential transcriptomic responses of the Takifugu rubripes larvae brain were compared after E₂ treatment for 55 days. Our results showed that 514 genes were differentially expressed between E₂-treated-XX (E-XX) and Control-XX (C-XX) T. rubripes, while 362 genes were differentially expressed between E₂

SUBMITTER: Shen X 

PROVIDER: S-EPMC8614003 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature