Development of outcome measures according to dystrophic phenotypes in canine X-linked muscular dystrophy in Japan.

ABSTRACT: Duchenne muscular dystrophy (DMD) is an X-linked lethal muscle disorder characterized by primary muscle degeneration. Therapeutic strategies for DMD have been extensively explored, and some are in the stage of human clinical trials. Along with the development of new therapies, sensitive outcome measures are needed to monitor the effects of new treatments. Therefore, we investigated outcome measures such as biomarkers and motor function evaluation in a dystrophic model of beagle dogs, canine X-linked muscular dystrophy in Japan (CXMD_J). Osteopontin (OPN), a myogenic inflammatory cytokine, was explored as a potential biomarker in dystrophic dogs over the disease course. The serum OPN levels of CXMD_J dystrophic dogs were elevated, even in the early disease phase, and thi

SUBMITTER: Kuraoka M 

PROVIDER: S-EPMC8614006 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature